The fecal microbial transplant (FMT) can be detected back in the 4th century, but in the last decade, the US Food and Drug Administration only approves their approval that the process has entered widespread exercises.
They are included as treatment Clostridium deficile or c. to separateA common bacterial infection that can cause inflammation and gastrointestinal issues.
FDA first approves FMT as a treatment C. DIFF Approved the first drug for FMT treatment in 2013 and in 2022.
Some people think that FMTs may be an option for the treatment of Crohn’s disease – a chronic autoimmune status – ulcerative colitis and irritable bow disorder.
But researchers warned in a study Published June 6, 2025, that FMT can introduce germs that may be potential to introduce new health risks, to correspond and thrill the host environment.
The study, which was performed in mice, human tissue samples and with a small volunteer group, found “mismatched”, donor fecal substances and destinations may have unexpected results on the recipient’s immune and metabolic work in a good environment.
“Even an FMT, host-microbo relationship will take a change in a very different field of thesis, which can be difficult to reverse,” said Eugene Chang, a senior writer of the study and a professor at the University of Chicago, USA, said.
How does a fecal transplant work?
Each human has a unique mixture of germs in its gastrointestinal tract – intestine. It contains trillions of bacteria, fungi, viruses and other microorganisms that perform biological duties within the body. Collectively, this collection of germs is called intestinal flowra.
For some people, this ecosystem of germs is interrupted by infection, autoimmune issues and other problems. This disrupted state is called intestinal dysbiosis.
FMT donors NEET to meet a range of requirements: For example, they should be free from blood -related infections, discovered as hepatitis and HIV, and they could not have intestinal issues.
Doctors usually do a colonoscopy to remove the feces of the donor and after further preparation, the recipient’s good insert the donor germs through a long tube.
Colonize
In the study, germs were taken from three separate areas of small and large intensity and transplanted into recipients of mice.
Each batch of the newly introduced intestinals as the researcher, as “terraform” – or, instead of taking the entire intestinal path of each mouse, saw only, instead of occupying the same rage from the donor’s intestine, or, as, or, as, or, as, or,
Colonial microbes changed genes and proteins to the tissues of recipient mice to create a more sociable environment – even at a microbial level, these launched species appeared to flourish.
An assessment in seven human volunteers in a month was found in a high level of micro -level micro -colonization in the small intestine.
Because this revised immune and metabolic functions, researchers say that more care should be given to design fecal transplant using specific, targeted microbes for the intestines.
A ‘Wake-up call’ for FMT field
The prominent writer of the study, Orlando Delen, the University of Chicago said, “There was a call awake in the field that we probably do not put Villi-Nili in different parts of the intestine in various parts of the intestine which should not be there.”
OMT -OMNI microbial implants – The administrator targets the specific intestinal region with germs as a pill or a batch of good intestinal flora through endoscopy. Delain said that this is a better way for fecal transplant.
Delain said, “The microbes that are considered are better favorable for this,” so they are more naturally going to fill it in the presence of other microbes. ,
DW approached the research group for further comments, but did not receive the response in time for publication.
Ed Kuizpar, Leiden University Medical Center, Netherlands expert, who was not involved in the study, told DW via email that the research “clearly reflects FMT. […] All humans and mice affect microbyota composition throughout the intestines. ,
But Kujpar said that he was concerned with the conclusion that the FMT leads to “microbyota mismatched” and “unexpected dogs” in various regions of the intestines.
The way the research team acknowledged the limitations of checking only seven human subjects in a month, Kuizpar said that more comprehensive evaluation in patients would be imported to assess the possible negative health results of fecal transplant.
“A more approved conclusion would be that FMT induces both small and large intestinal changes in mice, with systemic effects that vary depending on the affected area.
In Europe, Eurfmt in the Interorganization Group exchanged research and information, and maintained an continental regressive for the patient’s follower.
Edited by: Zulfiker Ebony
